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2.What is Glucosamine Sulfate?

Glucosamine sulfate is the salt of the natural amino-sugar glucosamine, which is normally synthesised in the healthy body and is the basic constituent of cartilage glycosaminoglycans and proteoglycans, i.e. the main substances that form the cartilage matrix and that are essential for cartilage health and function.

Glucosamine sulfate cannot be practically used as such for the preparation of medicinal products or dietary supplements because, for chemical reasons, it is a highly unstable compound. The Rotta Research Group has invented and patented several years ago a method to stabilize glucosamine sulfate, through a chemical process of co-precipitation with sodium chloride, thus obtaining Crystalline Glucosamine Sulfate. Crystalline Glucosamine Sulfate is the active ingredient in DONA™ and the original and only glucosamine sulfate that has been investigated in more than 150 pre-clinical and clinical studies, and to which over 90% of the scientific literature refers.

Crystalline Glucosamine Sulfate is referred to in this document of Frequently Asked Questions as Glucosamine Sulfate, for simplicity.


These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.