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| Has glucosamine hydrochloride the same effects of the original Glucosamine Sulfate contained in DONA? |
In theory, glucosamine hydrochloride, if given in adequate amounts, may have pharmacological effects similar to Glucosamine Sulfate if these effects are caused by the glucosamine molecule. Unfortunately, most if not all of the scientific studies available have been performed with the original Glucosamine Sulfate and it is not known if glucosamine hydrochloride may indeed have the same effects, since the sulfate part should play a significant role (see below).
In particular all clinical studies available have been performed with DONA, i.e. the original Glucosamine Sulfate, except one performed with glucosamine hydrochloride and that, although showing an interesting trend in favour of glucosamine hydrochloride compared to placebo, did not show the same favourable results expected after the experience with Glucosamine Sulfate.
No comparative studies have been performed and thus it can be concluded that the clinical efficacy and safety have been proven only for DONA, i.e. the original Glucosamine Sulfate.
All clinical studies performed with DONA and with other glucosamine-derived products are described in the Product Monograph of DONA.
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