|
|
|
Can DONA™ be combined with non-steroidal antiinflammatory drugs (NSAIDs)? |
State-of-the-art clinical trials have shown that the degree of the clinical improvement on the signs and symptoms of osteoarthritis with DONA™ is so strong after a standard 12-week treatment course for symptom-modification, that it can not even be differentiated from that obtained combining the compound with NSAIDs. Both DONA™ and the combination of DONA™ with an NSAID may be actually more effective than the NSAID alone.
However, the combined treatment has an onset of action over the first 2 weeks of administration that is even greater and faster than that of either drug alone. Therefore, the combination of DONA™ with NSAIDs may be advisable when an immediate therapeutic response is required. Alternatively, this association may be appropriate when the possible superimposed inflammatory component of the disease is clinically relevant.
It should be borne in mind that DONA™ has a safety which is similar to that of placebo and it is significantly better tolerated than NSAIDs. However, combining DONA™ with NSAIDs does not protect from the adverse reactions to the NSAID, although it may improve patient's compliance.
|
|
|
